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KMID : 0853020080110010027
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Journal of Korean Burn Society
2008 Volume.11 No. 1 p.27 ~ p.31
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The Effectiveness of Temporary Allograft Skin Coverage on Survival Rate in Massive Burns
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Jung Kuk-Hyun
Lee Boung-Chul
Seo Cheon-Hoon
Kim Do-Hern
Hur Jun
Chun Wook
Cho Yong-Suk
Kim Jong-Hyun
Yim Hae-Jun
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Abstract
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Purpose: The most common cause of death in massive burns is burn wound sepsis. Therefore temporary wound coverage with allograft skin to prevent wound infection after escharectomy has been the golden standard treatment. The
negative perception towards usage of allograft, insufficient experiences and lack of establishment of human tissue regulation prevented the treatment of using allograft skin grafts to burned patients in Korea. The authors have performed the first allograft skin coverage treatment in December, 2003 obtained from living donors (parents of massive pediatric burn patients) in Korea. Hereafter, Hangang Sacred Heart Hospital Burn Center has performed allograft (cadaver) coverage to 250 burn patients from December, 2003 to December, 2006. The study has been conducted to discover the effectiveness
of allograft in terms of survival rate in massive burn treatment.
Methods: We compared survival rates of non-allograft group (E group) of 738 patients with only escharectomy performed and 250 patients of allograft treated group (EA group). The comparisons are made based on main factors of burn area and age. The cross tabulation analysis and chi-square (χ2) tests are carried out to distinguish the presence of notable statistic data.
Results: The survival rate of the EA group treated with allograft after escharectomy was notably increased statistically compare to the E group with only escharectomy performed. The p-value was 0.035. There were no statistically notable survival rate between E group and EA group of 10∼40% TBSA burned. The p-value was 1.000. The survival rate of the EA group with 41∼70% TBSA burned was notably increased than E group. The p-value was 0.013. No notable statistic data showed from the group of 71∼100% TBSA burned patients. The p-value was 0.346.
Conclusion: Our study showed the usage of allograft after escharectomy on massive burn patients increases the survival rate. The allograft treatment is especially essential to those 41∼70% TBSA burned patients. (Journal of Korean Burn Society 2008;11:27-31)
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KEYWORD
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Survivalrate, Allograft, Burns
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